Children with rare diseases, orphans of medicine, are disadvantaged in many respects: endless odyssees from doctor to doctor, wrong diagnoses and clinical mismanagement determine their lives. Many rare diseases remain incurable up to date. Only through enhanced research activities and international cooperation can we change the fortune of many children. The Care-for-Rare supports children cross-borders in order to give them hope for treatment – no matter what nationality, ethnic origins and financial background they present.